Table 7.
Equation of the fitted model, correlation coefficient (r) and p-value of the multiple linear regression between urinary markers measured at 8 months and renal lesions at the end of the experiment (8 months old) in Zucker lean and Zucker obese rats (n = 20).
| 8 months | Equation of the fitted model | r | p |
|---|---|---|---|
| Glomerular esclerosis | Y = -0.356 + 0.0126Klotho + 0.0465Hyp | 0.8636 | <0.0001 |
| Glomerular hyperplasia | Y = 0.787 + 0.2265Prot + 0.0090Klotho | 0.9541 | <0.0001 |
| Increased mesangium | Y = 0.2661 + 0.2409Prot + 0.0193Klotho | 0.8032 | 0.0001 |
| Capsular fibrosis | Y = -0.118 + 0.0313Klotho | 0.8871 | <0.0001 |
| Glomerular cysts | Y = -0.158 + 0.0491Hyp | 0.5727 | 0.0083 |
| Tubular vacuolization | Y = 0.327 + 2.08AlaAp | 0.5799 | 0.0074 |
| Tubular atrophy | Y = -0.238 + 0.4153Prot + 0.0169Klotho | 0.9230 | <0.0001 |
| Casts | Y = -0.4564 + 0.7042Prot | 0.9346 | <0.0001 |
| Hyaline drops | Y = 0.2728 + 1.8015AlaAp | 0.5842 | 0.0068 |
| Inflammation | Y = -0.602 + 0.0181Klotho + 0.0664Hyp | 0.9181 | <0.0001 |
| Interstitial fibrosis (SR) | Y = 1.17 + 0.322Prot | 0.6805 | 0.0010 |
| Interstitial fibrosis (%) | Y = 12.9 + 4.46Prot | 0.8691 | <0.0001 |
| Renal Hyp | Y = 310 + 112AlaAp + 1.7623Klotho | 0.8154 | 0.0001 |
AlaAp, alanyl aminopeptidase; Prot, proteinuria; Hyp, hydroxyproline; Hyp, hydroxyproline; SR, Sirius red.