Table 1:
Performance of different antigen detection systems in the diagnosis of human VL
| Sample | Test | No. of subjects | Sensitivity (%) | Specificity (%) | Country | Ref. | ||
|---|---|---|---|---|---|---|---|---|
| VL patients | Other diseases | Healthy control | ||||||
| Urine | KAtex | 25 | 34 | 312 | 68 | 100 | Brazil | (64) |
| Urine | KAtex | 29 | 23 | 312 | 100 | 100 | Yemen | (64) |
| Urine | KAtex | 5 | - | 312 | 86 | 100 | Nepal | (64) |
| Urine | KAtex | 62 | 16 | 158 | 95.2 | 100 | Sudan | (73) |
| Urine | KAtex | 155 | 77 | - | 47.7 | 98.7 | Nepal | (74) |
| Urine | KAtex | 382 | - | 185 | NR | 99 | India | (75) |
| Urine | KAtex | 85 | 57 | - | 57 | 98 | Nepal | (25) |
| Urine | KAtex | 63 | - | 38 | 57.4 | 84.3 | Ethiopia | (68) |
| Urine | KAtex | 282 | 70 | 100 | 67 | 99 | India | (76) |
| Urine | KAtex | 33 | - | 35 | 100 | 91.4 | Bangladesh | (77) |
| Urine | KAtex | 313 | 14 | 57 | 77.7 | 98.2 | Iran | (78) |
| Urine | KAtex | 38 | - | - | 71 | 64 | Ethiopia | (15) |
| Urine | KAtex | 308 | - | - | 84.5 | 87.8 | Kenya | (15) |
| Urine | KAtex | 294 | - | - | 72.9 | 98.3 | Sudan | (15) |
| Urine | KAtex | 352 | - | - | 66.1 | 87.6 | India | (15) |
| Urine | KAtex | 158 | - | - | 35.8 | 97.8 | Nepal | (15) |
| Urine | KAtex | 50 | - | 50 | 94 | 98 | Bangladesh | (79) |
| Urine | KAtex | 36 | - | 40 | 75 | 100 | Bangladesh | (80) |
| Urine | KAtex | 46 | 30 | 46 | 61 | 92 | Ethiopia | (81) |
| Urine | KAtex | 13 | 30 | 46 | 69 | 92 | Bangladesh | (81) |
| Urine | KAtex | 43 | 30 | 46 | 56 | 92 | Brazil | (81) |
| Urine | KAtex | 100 | - | 50 | 87 | 100 | Bangladesh | (69) |
| Urine | Antigen™ Detect ELISA | 46 | 30 | 46 | 93.5 | 100 | Ethiopia | (81) |
| Urine | Antigen™ Detect ELISA | 64 | 30 | 46 | 96.9 | 100 | Sudan | (81) |
| Urine | Antigen™ Detect ELISA | 13 | 30 | 46 | 100 | 100 | Bangladesh | (81) |
| Urine | Antigen™ Detect ELISA | 43 | 30 | 46 | 88.4 | 100 | Brazil | (81) |
| Urine | Capture ELISA | 35 | 24 | 10 | 60 | 91.2 | Iran | (17) |
| Urine | Capture ELISA | 34 | - | 104 | 94.1 | 100 | Yemen, Nepal, Spain, Sudan, Brazil | (62) |