Fig. 2.

Genome mining of lyciumins in plants. (A) Precursor gene-guided genome mining of lyciumins. (B) Structural diversity of lyciumins characterized by genome mining from Amaranthaceae, Fabaceae, and Solanaceae plants. The stereochemistry of glycine α-carbon is inferred from lyciumin A and lyciumin I structure elucidation. (C) Types of lyciumin precursors based on primary structure analysis (Dataset S1). Core, core peptide. (D) Phylogenetic relationship of plant families with predicted and characterized (noted by asterisks) lyciumin chemotypes (both highlighted in red).