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Time‐dependent changes in the ratio of (A) tetranor‐PGDM/Cre and (B) tetranor‐PGEM/Cre in pooled urine in the repeated‐dose period. Mean + standard deviation (n = 3–5). Day 0 = pre‐dose. PGDM, prostaglandin D metabolite; Cre, creatinine; PGEM, prostaglandin E metabolite.
