Figure 1.

Phosphorylated alpha synuclein deposits are more expressed in PD. Confocal images of immunofluorescence with PGP9.5 (green) and p‐αSyn (red) of dermal nerves around sweat glands in PD T0 (A–B), in AP‐SYN (D–E), AP‐TAU (G–H), and healthy subject (J–L). In yellow colocalization of p‐αSyn and PGP 9.5 (C,F,I,M) along axons. Scale bar 50 μm. White arrows indicate positive structures, asterisks indicate unspecific staining in non‐neuronal structures. The percentage of p‐αSyn is higher in PD T0 patients compared to other groups (P = 0.028) (N), but is not different among localizations (O). A major colocalization area p‐αSyn/PGP9.5 was measured in PD with a proximal to distal gradient (P). PD, Parkinson disease.