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. 2018 Oct 14;5(11):1394–1407. doi: 10.1002/acn3.669

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© 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Cervical skin denervation correlates to disease duration and significantly increases at 12 months follow‐up. IENFD is lower in PD T0 patients compare to AP‐TAU and HC subjects (P < 0.03), but not compared with AP‐SYN (A). Total IENFD is significantly reduced in PD females versus PD males (P = 0.012), in PD females versus HC females (P = 0.002) and versus AP‐TAU (P < 0.001) (B). In PD after 12 months IENFD is significantly lower at the thigh (P = 0.002) and at the cervical site (P = 0.001) (C). Western blot of skin lysates (an example) (D). Densitometry of PGP9.5 and β‐actin bands measured by LICOR software (n = 12 PD, n = 8 HC) PGP9.5 values normalized to β‐actin, show a major denervation at cervical site (P < 0.05) (E). PGP9.5 quantification negatively correlates to disease duration at cervical site in PD at T0 (F).