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. 2018 Oct 8;13(11):3206–3216. doi: 10.1021/acschembio.8b00864

Figure 3.

Figure 3

Assessment of the hematological toxicity of imidazotetrazines in vivo. Mice were administered a single IV dose of 125 mg/kg imidazotetrazine. After 7 days, whole blood was collected, and a complete blood count was obtained for each individual mouse. (a) Total WBC count. Control vs Ox-TMZ: P = 0.7, Control vs K-TMZ: P = 0.9. (b) Lymphocyte concentrations. Control vs Ox-TMZ: P = 0.5, Control vs K-TMZ: P = 0.9. Error is SEM, number of mice per cohort = 4. Statistical significance was determined by using a two-sample Student’s t test (two-tailed test, assuming equal variance). The concentrations of other relevant blood constituents can be found in Supporting Information Figure S3.