Table 1. Panel of C8-Substituted Imidazotetrazines and Associated IC₅₀ Values (μM) in Multiple GBM Cell Lines^a.

^aCell lines were incubated with compound for 7 days, and then viability was assessed using the Alamar Blue assay. Error is SEM, n ≥ 3. Prl = pyrrolidine. A table with additional compounds (Table S1) and a Western blot for MGMT status of all cell lines used (Figure S1) can be found in the Supplementary Information.