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. 2018 Nov 1;14:1744806918810099. doi: 10.1177/1744806918810099

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Comparison of 50% mechanical withdrawal threshold. Withdrawal threshold to mechanical stimulation of the plantar surface of the ipsilateral hind paw with von Frey filaments was recorded on the same day (day 21–27) immediately prior to acute electrophysiological experiment. Animals in neuropathic pain (NEP) and cancer-induced pain (CIP) groups demonstrated reduced mechanical withdrawal thresholds relative to control. (SD-control: Naïve control of Sprague-Dawley (SD) rat, SD-NEP: SD rat NEP model, SD-CIP: SD rat breast cancer-induced bone pain (CIP) model, CP-Control: Copenhagen (CP) rat sham-surgery control of CIP model, CP-CIP: CP rat prostate CIP model). Asterisks above the graph indicate significant differences between control and NEP/CIP animals: **P < 0.01, ***P < 0.001. The absence of an asterisk indicates a lack of a statistically significant difference. Kruskal–Wallis tests with post hoc Dunn’s multiple comparison tests were used to compare SD rat groups, and Mann–Whitney U testing was used to compare CP rat groups.