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. 2018 Nov 13;8:397. doi: 10.3389/fcimb.2018.00397

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Copyright © 2018 Boussoffara, Chelif, Ben Ahmed, Mokni, Ben Salah, Dellagi and Louzir.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between granzyme B levels, LST reactivity and presence of typical ZCL scar. (A) Grz B level expressed in function of result of LST. n number of individual for each group. (B–D) Histograms represent mean values of Grz B levels measured in culture supernatants of PBMCs from individuals, categorized basing on categorical results of LST (LST⁺/LST⁻) and presence or absence of ZCL scars (scar⁺/scar⁻). (E,F) Categorial result for Grz B expression within individuals categorized basing on LST results (LST⁺/LST⁻) or presence or absence of scar (scar⁺/scar⁻). Grz B⁺: Grz B levels ≥2 ng/ml, Grz B⁻: Grz B levels <2 ng/ml. LST⁺, Diameter of induration ≥5 mm; LST⁻, Diameter of induration <5 mm.