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. 2018 Nov 13;12:273. doi: 10.3389/fnbeh.2018.00273

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Copyright © 2018 Kang, Ha, Park, Nam, Suh, Suh and Chang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of cx-DHED on phosphorylated tau deposits. (A) Immunostained brain tissues with the AT-8 antibody in WT-v, WT-cx-DD, Tg-v, Tg-cx-DD, and Tg-DP. Scale bars, 40 × . a–d: the cortex (a,c) and dentate gyrus (b,d) of the hippocampal region are enlarged images of square box in Tg-v and Tg-cx-DD, scale bars, 100 × . (B,C) Phosphorylated tau counts in CX (B) and DG (C) of the hippocampal region decreased in Tg-cx-DD mice. Scale bars, 100 × . All data were given as means ± standard error of the mean (SEM) (N = 4 mice per group). *P<0.05, **P<0.01 compared with WT-v mice, ^#P<0.05, ^##P<0.01 compared with Tg-v mice.