Figure 4.

A10E significantly prevented surgery-induced impairment of spatial learning and memory in the early stage. The 1st MWM test was performed on days 8–12 post operation. (A) In the training trials of the 1st MWM test, treatment with A10E at 0.6 mg/kg significantly reduced the escape latency at the last day of test in surgery-treated mice. (B) In the probe trial session of the 1st MWM test, A10E treatment at 0.6 mg/kg significantly increased the time duration spent by animals in the target quadrant in surgery-treated mice (n = 8). ^#p < 0.05 vs. the control group, *p < 0.05 vs. the surgery group (Dunn’s multiple comparison test).