Figure 5.

A10E significantly prevented surgery-induced impairment of recognition in the late stage. The 2nd NOR test was performed on days 24–26 post-operation. (A) In the training session of the 2nd NOR test, treatments did not significantly change the recognition index in aged mice. (B) In the retention session of the 2nd NOR test, treatment with A10E at 0.4–0.6 mg/kg significantly prevented the reduction of recognition index in surgery-treated mice (n = 8). ^#p < 0.05 vs. the control group, *p < 0.05 vs. the surgery group (Dunn’s multiple comparison test).