Table 2.
entry | halide source | Tres (min) | flow rate (μL/min) | recovered 1 (%)a | yield 2 (%)a | yield 3 (%)a |
1 | NaBr | 60 | 216 | 89 | <5 | <5 |
2 | NaBr | 120 | 110 | 47 | 53 | – |
3 | NaBr | 240 | 54.2 | 45 | 32 | 23 |
4 | TBAB | 240 | 110 | – | 21 | 63 |
5 | NaBr | 240 | 110 | – | 91(83)b | – |
aYield determined by analysis of 1H NMR. bYield determined by isolation via chromatography.