Table 3.
Age estimates of the CFTR p.Phe508del in the different populationsa
| Population | #Haplotypes | #Generations | #Years | 95% CI in years | Ancestral haplotypeb | |
|---|---|---|---|---|---|---|
| Low | High | |||||
| Albania | 16 | 52 | 1300 | 850 | 2050 | 206_114_199_276_300_253_F508del_221_319_279_240 |
| Austria | 21 | 143 | 3575 | 2575 | 5075 | 200_120_199_276_302_253_F508del_227_305_287_240 |
| Czech Republic | 14 | 128 | 3200 | 2125 | 4950 | 208_124_197_280_302_253_F508del_223_305_287_240 |
| Denmark | 24 | 184 | 4600 | 3350 | 6400 | 200_122_197_276_300_253_F508del_227_305_283_240 |
| France | 22 | 184 | 4600 | 3300 | 6575 | 210_122_199_276_300_253_F508del_223_305_283_244 |
| Greece | 20 | 47 | 1175 | 800 | 1750 | 206_114_199_276_300_253_F508del_221_319_279_240 |
| Ireland | 10 | 189 | 4725 | 2925 | 8125 | 206_108_195_276_300_253_F508del_223_305_279_246 |
| Ukraine | 5 | 86 | 2150 | 1050 | 4625 | 208_120_199_276_306_253_F508del_227_323_271_240 |
| USA(Germany-derived) | 16 | 185 | 4625 | 3150 | 7025 | 200_118_199_276_300_253_F508del_227_305_283_240 |
aIn each population, the total number of haplotypes included in the analysis (only haplotypes with no ambiguity were kept and one haplotype was randomly chosen for homozygous carriers) and age estimates in number of generations and in years (assuming 1 generation = 25 years) with the lower and upper bound of the 95% confidence interval are listed
bThe last column gives the imputed ancestral haplotype in each population