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. 2018 Nov 20;4:105. doi: 10.1038/s41420-018-0124-8

Fig. 6. Apigenin disrupted YAP/TAZ and TEAD interaction in TNBC cells.

Fig. 6

a, b MDA-MB-231 and MDA-MB-436 cells were treated with DMSO vehicle or apigenin (5, 10, and 20 µM) for 72 h. The cells were harvested, and the effect of apigenin on the YAP/TAZ and TEADs interaction was analyzed by immunoprecipitation assay. c, d TAZ knockout sensitized TNBC cells to apigenin treatment. Both Scramble and sgTAZ cells were treated with apigenin (0–64 μM) for 48 h, and cell viability was measured via the SRB assay. e Schematic diagram of the mechanism of apigenin-mediated antitumor activity by inhibiting YAP/TAZ activity in TNBC cells. Apigenin inhibited YAP/TAZ activity and decreased the expression of downstream genes by targeting YAP/TAZ-TEAD protein–protein interaction