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. 2018 Nov 20;8:17135. doi: 10.1038/s41598-018-35230-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between co-abundance network topological features and depleted ESVs in human and mice fecal samples. Relationships between normalized abundance of the human ESVs (see Fig. 5) that were depleted in both lean Ghanaians and in humanized mice with fecal materials from the lean Ghanaians, showing their (a) betweenness centrality, (b) closeness centrality, (c) closeness and (d) transitivity. Each panel indicates the results from the Spearman correlation test. (e) Closeness is distinct between the ESVs associated with the depleted lean Ghanaians (p < 0.001 for all the group). For (e), GL, lean Ghanaians; GO, obese Ghanaians; UL, lean Americans; and UO, obese Americans.