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. 2018 Nov 20;9:4888. doi: 10.1038/s41467-018-07196-9

Table 1.

Hydrofluorination of 1a with N-fluoro-N-(aryl)arenesulfonamides 4a–4i

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Entry F-reagent yield [%]a Initiator (equiv) Solvent T (°C) 2a
1 4a DTBHN (0.1) DMF 80 30
2 4a DTBHN (0.1) Benzene 80 –
3 4a DTBHN (0.1) CH3CN 80 –
4 4a DTBHN (0.5) DMF 80 45
5 4a DTBHN (1) DMF 80 45
6 4b DTBHN (0.5) DMF 80 9
7 4c DTBHN (0.5) DMF 80 23
8 4d DTBHN (0.5) DMF 80 30
9 4e DTBHN (0.5) DMF 80 41
10 4 f DTBHN (0.5) DMF 80 47
11 4 g DTBHN (0.5) DMF 80 43
12 4 h DTBHN (0.5) DMF 80  41
13 4i DTBHN (0.5) DMF 80 40
14 4a DTBPO (0.5) DMF 60 47
15 4 f DTBPO (0.5) DMF 60 51

aYields determined by GC using n-undecane as an internal standard