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. 2018 Nov 20;8:17139. doi: 10.1038/s41598-018-35484-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pendimethalin-induced histopathology in rat liver (×400). Panel a: liver of control rat showing normal histological appearance including Kupffer cell (KC), central vein (CV), hepatic cells (HC), blood sinusoids (BS) and centrally located nuclei (N). Panels b–d: liver sections of PND treated animals at lower, middle and high doses, exhibiting appearance of swelling, hyperplasia (H), pyknotic nuclei (PN), necrosis (NR), leukocyte infiltrations (LI), dilatation in blood sinusoids (DBS), activated Kupffer cells (AKC), large vacuolation (V), damage of hepatocytes (DHC), congested blood vessel (CBV) and hyperplasia (H). Each photomicrograph represents a section from an individual treated group of rat liver.