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. 2018 May 7;20(6):952–962. doi: 10.1007/s11307-018-1201-3

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — SPECT imaging reveal decreased perfusion after LPS injection. Cerebral blood perfusion was measured by [^99mTc]HMPAO. SPECT coregistration with computed tomography (CT) showing [^99mTc]HMPAO uptake in a control and b LPS-treated animals. Arrows indicate areas where the difference in radiotracer uptakes between the two groups is observable. c [^99mTc]HMPAO uptake is significantly reduced 5 h after the LPS injection in all examined brain regions (cerebrum: indicates the whole brain without cerebellum, cerebellum, cortex, and hippocampus; *p ≤ 0.05; **p < 0.01; ***p < 0.001—one-sided permutation test).