Fig. 4.

PET imaging after LPS injection. Cerebral glucose transport and metabolism was measured by [¹⁸F]FDG. Summarized PET signal during a 3 min time frame starting at 7 min post injection and ending at 10 min post injection of [¹⁸F]FDG is co-registered with CT showing [¹⁸F]FDG uptake in a control and b LPS-treated animals. Arrows indicate example areas where the difference in radiotracer uptakes between the two groups is visually discernable. c [¹⁸F]FDG uptake is significantly increased 6 h after the LPS injection in cerebrum—defined as the whole brain without the cerebellum, cerebellum, and cortex. Relevant but not significant changes were registered in hippocampus (p = 0.057) (***p < 0.001—one-sided permutation test).