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. 2018 May 7;20(6):952–962. doi: 10.1007/s11307-018-1201-3

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — P2Y12 and CD45 double-labeling immunohistochemistry before and after LPS treatment. Representative photomicrographs from the hippocampus. All scale bars correspond to 50 μm. a P2Y12 brain immunostaining of control animals reveals ramified, P2Y12+ microglia in all brain regions (parietal cortex, hippocampus, and cerebellum). b The CD45 immunostaining of the same area reveals very low CD45 immunoreactivity. c P2Y12 staining reveals activated microglia cells with enlarged cell bodies and thickened processes in LPS-treated animals (arrowheads). d Double labeling with CD45 shows the CD45^low expression of the corresponding cells (arrowheads). e The percentage of activated/all microglia based on morphology and CD45 expression. f The number of activated microglia per brain area.