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. 2018 Aug 30;20(6):888–901. doi: 10.1007/s11307-018-1267-y

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — Selection of IMC images from various applications adapted from [53, 54]. (a) Tissue architecture: representative total ion current image (left) of mouse abdominal wall, overlay of three tissue type markers (middle) β-actin, histone H3 and iridium DNA intercalator, (right) E-cadherin, collagen and αSMA. (b) Functional markers: representative IdU, ¹⁹⁵Pt and histone H3 images of control and cisplatin-dosed (4 mg/kg for 24 and 48 h) small mouse intestine. (c) Tumour microenvironment (TME): pancreatic cancer patient–derived xenograft (PDX) assessment using EF5 tracer, E-cadherin and Ki-67. (d) Target engagement: control and dosed pancreatic cancer PDX tissue evaluation.