FIGURE 2.

Regression models with global gray matter volume. Associations of EDE cargo proteins with total gray matter volumes. This figure shows leverage residuals plots of global gray matter volumes regressed on normalized EDE cargo biomarkers. Units for gray matter volumes entered into the model are mm³. Age in years and total intracranial volumes in mm³ were controlled for in all regressions. R² values are adjusted for number of predictors in regression model. All values are rounded to two significant digits. GM, gray matter; blue stars, controls; purple dashes, cases.