Table 1.
Tissue and donor characteristics
| Donor | Tissue | Location | Etiology | Age | Previous treatment | Skin color | Pt age | Gender |
|---|---|---|---|---|---|---|---|---|
| 1 | Nskin | Breast | NA | NA | NA | − | 40 yrs | Male |
| 2 | Nskin | Breast | NA | NA | NA | White | 34 yrs | Male |
| 3 | Nskin | Abdomen | NA | NA | NA | Dark brown | − | Female |
| 4 | Nskin | Abdomen | NA | NA | NA | White | 59 yrs | Female |
| 5 | Nskin | Abdomen | NA | NA | NA | − | 49 yrs | Female |
| 6 | Nskin | Breast | NA | NA | NA | Dark brown | 20 yrs | Female |
| 7 | Nskin | Leg | NA | NA | NA | White | − | − |
| 8 | Nskin | Abdomen | NA | NA | NA | Dark brown | 39 yrs | Female |
| Kscar is subdivided into P-Kscar, Cs-Kscar and Cd-Kscar | ||||||||
| 9 | Kscar | Earlobe | Piercing | 4 yrs | None | Light brown | 46 yrs | Female |
| 10 | Kscar | Neck | Insect bite | 8 yrs | Excision; Corticosteroids | Dark brown | 15 yrs | Female |
| 11 | Kscar | Abdomen | Surgery | 6 mo | None | Dark brown | 23 yrs | Female |
| 12 | Kscar | Earlobe | Piercing | 1 yr | Excision; Corticosteroids | Dark brown | 17 yrs | Female |
| 13 | Kscar | Sternum | Skin irritation | 12 yrs | Excision | Dark brown | 39 yrs | Female |
| 14 | Kscar | Retroauricular | − | − | None | White | 15 yrs | Male |
| 15 | Kscar | Pubic region | Inflammation | > 1 yr | None | Dark brown | 46 yrs | Female |
| 16 | Kscar | Ear | Surgery | 4 yrs | None | White | 11 yrs | Female |
| sNskin was derived from normal skin directly adjacent to keloid scars | ||||||||
| 17 | sNskin | Pubic region | − | 6 yrs | − | Dark brown | 19 yrs | Female |
| 13 | sNskin | Sternum | Skin irritation | 12 yrs | Excision | Dark brown | 39 yrs | Female |
| 8 | sNskin | Abdomen | − | − | − | Dark brown | 39 yrs | Female |
| 18 | sNskin | Breast | Surgery | > 1 yr | None | Dark brown | 43 yrs | Female |
| 15 | sNskin | Pubic region | Inflammation | > 1 yr | None | Dark brown | 46 yrs | Female |
Overview of the characteristics of the tissue used for this study. All the skin models were constructed using donor matched keratinocytes and fibroblasts, note that all the tissues with the same donor number originate from the same patient
NA not applicable, yr(s) year(s), mo months, Nskin normal skin (n = 8), P-Kscar peripheral keloid (n = 8), Cs-Kscar central superficial keloid (n = 7), Cd-Kscar central deep keloid scar (n = 7), sNskin surrounding normal skin (n = 5), − no information available. See Table 3 for further clarification of skin model donor matching and number of biological replicates (‘n’) per experiment