Fig. 2.

Change from baseline in weekly mean pain score (daily pain NRS; ITT population). *Unadjusted p < 0.05 from MMRM analysis. Changes in weekly mean pain score ± standard error were estimated from mixed-model repeated measures (MMRM) model. Weekly mean pain numerical rating scale (NRS) scores are derived from the daily pain NRS and calculated as the mean of the available scores in the 7 days. Generally, week “n” mean pain score is defined as the mean of the 7 daily diary pain ratings from day 2 + 7*(n–1) to day 1 + 7*n. At least four entries within the last 7 days are required to calculate a mean score. NRS ranged from 0 (“no pain”) to 10 (“worst possible pain”), with higher scores indicating increased pain. ITT intention to treat