Table 3.
Tissue concentrations of radioactivity after single oral administration of 14C-amenamevir to mice at 3 mg/kg
| Tissue | Mean concentration (ng eq./g or mL) | |||
|---|---|---|---|---|
| 0.5 h | 1 h | 4 h | 24 h | |
| Blood | 305 | 365 | 165 | 7.08 |
| Plasma | 349 | 422 | 186 | BLQ |
| Brain | 25.9 | 32.6 | 18.0 | BLQ |
| Spinal cord | 33.3 | 41.6 | 20.0 | BLQ |
| Hypophysis | 865 | 921 | 590 | BLQ |
| Eyes | 153 | 202 | 103 | BLQ |
| Harderian glands | 1890 | 2330 | 1010 | 13.4 |
| Submaxillary glands | 793 | 969 | 387 | BLQ |
| Thyroid glands | 959 | 896 | 372 | BLQ |
| Thymus | 387 | 526 | 233 | BLQ |
| Heart | 824 | 987 | 419 | 3.53 |
| Lungs | 644 | 681 | 333 | 2.04 |
| Liver | 8850 | 8450 | 3980 | 21.2 |
| Spleen | 527 | 587 | 275 | BLQ |
| Pancreas | 1130 | 1230 | 570 | BLQ |
| Adrenals | 750 | 1020 | 333 | BLQ |
| Kidneys | 1880 | 2080 | 988 | 4.23 |
| Epididymides | 316 | 402 | 283 | BLQ |
| Testes | 32.1 | 75.0 | 95.6 | BLQ |
| Skeletal muscle | 388 | 450 | 210 | BLQ |
| Skin | 210 | 251 | 140 | BLQ |
| Fat | 334 | 417 | 180 | BLQ |
| Femur | 63.8 | 117 | 44.8 | BLQ |
| Urinary bladder | 319 | 426 | 288 | BLQ |
| Stomach | 5480 | 1020 | 827 | 5.35 |
| Small intestine | 5010 | 6370 | 1670 | BLQ |
| Large intestine | 500 | 1240 | 3060 | BLQ |
Each value represents the mean of three animals
BLQ below the limit of quantitation