Fig. 1.

Legend: traditional model of wound healing. Wound healing normally progresses through the hemostasis/inflammatory phase, the proliferative phase, and the remodeling phase. Hemostasis is achieved with production of a fibrin clot. Danger signals are released from platelets and damaged cells, which leads to infiltration and activation of pro-inflammatory cells such as neutrophils and inflammatory-type macrophages. There is an important transition from the inflammatory to the proliferative phase (days 2–5). In chronic wounds, this transition often fails to occur. In the proliferative phase, extracellular matrix (ECM) is laid down to form granulation tissue, and angiogenesis and re-epithelialization occur. Over the next year, the granulation tissue is remodeled into a scar