Fig. 1.

Simulations on population-predicted plasma concentration-time profile of (R)- and (S)-ibuprofen. Population predictions without inter-patient variability were performed for one typical neonate with a body weight of 840 g. A gray reference line indicates the (S)-ibuprofen target concentration. In Figs. a–e: Plasma concentrations of the separate (R)- and (S)-enantiomers were simulated with the PK model of Gregoire et al. [23] starting at a postnatal age of 24 h. In Fig. f: Plasma concentrations of racemic ibuprofen ((R) and (S) not separately) were simulated with the PK model of Hirt et al. [12] starting at a postnatal age of 96 h. Abbreviation: MD maintenance dose