Table 1.
Population predicted (S)-ibuprofen concentrations following simulation of various intravenous ibuprofen-dosing regimens
| First dose (mg kg−1) |
MD (mg kg−1) |
Duration (days) |
Cumulative dose (mg kg−1) |
Pop pred Ctrough T48 after start (mg l−1) | Pop pred Cpeak T48.5 after start (mg l−1) | |
|---|---|---|---|---|---|---|
| a | 20 | 10 every 24 h | 3 | 40 | 42.5 | 70.4 |
| b | 10 | 5 every 24 h | 3 | 20 | 22.2 | 35.2 |
| c | 10 | 2.5 every 12 h | 3 | 22.5# | 26.5 | 32.9 |
| d | 18 | 4 every 12 h | 3 | 38 # | 43.8 | 54.9 |
| e | 14 | 6.5 continuously | 3 | 27 | 40.9 | 41.4 |
Simulations for a typical neonate with PDA with body weight 840 g, and PNA of 24 h
#On day 1, the first dose was followed by the first maintenance dose at 12 h
MD maintenance dose, Pop pred population predictions, T time after start of ibuprofen therapy