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. 2018 Jun 1;17(4):761–779. doi: 10.1007/s11047-018-9686-x

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — A simple switch turned into an oscillator. a The Two Intermediates (TI) system, that is behaving like a switch and emulating the behaviour of AM. b The Spontaneous Oscillator (SO) system is derived from TI and functions as robust oscillator. Solid arrows represent catalytic transitions with ball end arrows showing the activator of transitions, grey empty arrows represent first order conversions. c Representation of the KaiABC system of the cyanobacteria circadian clock (Loza-Correa et al. 2010), where KaiC hexamers are helped to convert themselves between forms that are phosphorylated an unphosphorylated at two critical sites (labelled T and S). KaiA (blue triangle) facilitates the phosphorylation reactions, while KaiB (yellow rod) helps the dephosphorylation reactions. (Color figure online)