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Pooled dose–response association between age at menarche and the risk of developing GDM in pregnancy (represented by the solid line) relative to the risk associated to an age of menarche of 13 years. Age at menarche was modelled with restricted cubic splines in a multivariate random effects dose response model. The relative risks of developing GDM are plotted on the log scale. The dashed lines show the 95% confidence intervals for the spline model
