Table 1.

Diagnosing and staging of acute kidney injury in liver failure [7, 8, 11, 12, 24, 25]

Revised definitions for the diagnosis and staging of AKI in liver failure
Baseline SCr: a value of SCr obtained in the previous 3 months, when available, can be used as baseline SCr. In patients with more than one value within the previous 3 months; the value closest to the admission time to the hospital should be used.
In patients without a previous SCr value, the SCr value on admission should be used as baseline. Definition of AKI:  • Increase in SCr of ≥ 0.3 mg/dl (≥ 26.5 mmol/L) within 48 h; or  • A percentage increase in SCr of ≥ 50% from baseline ,which is known, or presumed, to have occurred within the prior 7 days
No response: no regression of AKI Partial response: regression of AKI stage with a reduction of SCr to ≥ 0.3 mg/dl (26.5 μmoll/L) above the baseline value Full response: return of SCr to a value within 0.3 mg/dl (26.5 μmol/L) of the baseline value.
Staging of AKI (ICA-AKI criteria)  • Stage 1: increase in SCr of ≥ 0.3 mg/dl (26.5 μmol/L) or an increase in SCr of ≥ 1.5- to 2-fold from baseline.  • Stage 2: increase in SCr of > 2- to 3-fold from baseline  • Stage 3: increase of SC of  > 3-fold from baseline or SCr of ≥ 4.0 mg/dl (353.6 μmol/L) with an acute increase of ≥ 0.3 mg/dl (26.5 μmol/L) or initiation of renal replacement therapy

AKI, Acute kidney injury; SCr, serum creatinine; A ICA, International Club of Ascites