Table 2.
Steatohepatitis histology stratified by timing of liver biopsy in patients with nonalcoholic fatty liver disease
| Parameter | Patients undergoing liver biopsy after an overnight fast (N = 63) | Patients undergoing liver biopsy at 5 h after an OGTT (N = 83) | P | |
|---|---|---|---|---|
| Matteoni classification | ||||
| Type I: steatosis alone | 3 (4.8) | 7 (8.4) | 0.20 | |
| Type II: steatosis with inflammation | 19 (30.2) | 15 (18.1) | ||
| Type III–IV: steatosis with ballooning and/or fibrosis | 41 (65.1) | 61 (73.5) | ||
| NAS score | ||||
| 0–2 (%) | 3 (4.8) | 8 (9.6) | 0.11 | |
| 3–4 (%) | 35 (55.6) | 32 (38.6) | ||
| 5–8 (%) | 25 (39.7) | 43 (51.8) | ||
| Lobular inflammation | ||||
| None (%) | 0 | 4 (6.3) | 8 (9.6) | 0.87 |
| < 2 (%) | 1 | 45 (71.4) | 55 (66.3) | |
| 2–4 (%) | 2 | 13 (20.6) | 19 (22.9) | |
| > 4 (%) | 3 | 1 (1.6) | 1 (1.2) | |
| Ballooning | ||||
| None (%) | 0 | 22 (34.9) | 22 (26.5) | 0.24 |
| Few (%) | 1 | 36 (57.1) | 47 (56.6) | |
| Many (%) | 2 | 5 (7.9) | 14 (16.9) | |
| Steatosis grade | ||||
| < 5% (%) | 0 | 0 (0.0) | 0 (0.0) | 0.39 |
| 5–33% (%) | 1 | 27 (42.9) | 43 (51.8) | |
| 34–66% (%) | 2 | 21 (33.3) | 27 (32.5) | |
| > 67 (%) | 3 | 15 (23.8) | 13 (15.7) | |
| Fibrosis stage | ||||
| 0 (%) | 14 (22.2) | 15 (18.1) | 0.12 | |
| 1 (%) | 31 (49.2) | 28 (33.7) | ||
| 2 (%) | 10 (15.9) | 19 (22.9) | ||
| 3 (%) | 4 (6.3) | 15 (18.1) | ||
| 4 (%) | 4 (6.3) | 6 (7.2) | ||
Values are presented as N, N (%). Fisher’s exact tests were used to investigate the difference for each parameter between patients undergoing liver biopsy after an overnight fast or at 5 h post-OGTT
OGTT oral glucose tolerance test, NAS the NAFLD activity score