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. 2018 Sep 12;67(12):1853–1862. doi: 10.1007/s00262-018-2236-7

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Treatment of Lewis lung cancer mouse models with GM.CD40L plus CCL21 decreases tumor volumes and increases time to progression. Mice were inoculated with tumor cells on day 0 and vaccinated on day 5 and then three more times every 3 to 4 days. Tumor volume was measured. At the end of the study, lymph-node cells and splenocytes were harvested. Time to tumor progression increased significantly in all vaccine-treated mice; however, mice treated with GM.CD40L.CCL21 had a longer time to progression and an overall smaller tumor volume (p = .038)