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. 2018 Sep 17;172(3):587–595. doi: 10.1007/s10549-018-4951-3

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — a Specimen mammography showing a centrally located IDC + DCIS lesion. b Reconstructed micro-CT slice similarly shows a centrally located lesion. c Orthogonal micro-CT slices 12.1 mm apart reveal a close (≤ 2 mm) anterior margin (orange arrow) and a pathologically positive deep margin (red arrow), which agreed with the final pathologic diagnosis. Micro-CT scale bar is 1 cm. d 3D volume rendering of the specimen, with the adipose tissue thresholded to be transparent, shows the architecture of the lesion and its spiculations (see video in Additional File 2)