Table 3.
Top fifteen KEGG pathways, their respective p value, number of targets, and DE miRNAs observed among the MCF10A/HCC1806-EVs and control groups (presented according to the number of DE miRNAs)
| KEGG pathway | p value | # genes | # miRNAs |
|---|---|---|---|
| Pathways in cancer | 2.49E−05 | 282 | 63 |
| PI3K-Akt signaling pathway | 0.003893 | 228 | 62 |
| Ras signaling pathway | 0.000135 | 159 | 59 |
| Neurotrophin signaling pathway | 0.000411 | 90 | 59 |
| FoxO signaling pathway | 0.00135 | 97 | 58 |
| Focal adhesion | 0.006598 | 142 | 58 |
| cGMP-PKG signaling pathway | 0.019202 | 113 | 58 |
| Proteoglycans in cancer | 2.47E−06 | 146 | 57 |
| Sphingolipid signaling pathway | 0.003494 | 82 | 57 |
| Transcriptional misregulation in cancer | 0.014825 | 117 | 57 |
| Regulation of actin cytoskeleton | 0.018333 | 144 | 57 |
| Insulin signaling pathway | 0.022425 | 97 | 57 |
| Hippo signaling pathway | 2.47E−06 | 112 | 56 |
| Rap1 signaling pathway | 0.0003 | 150 | 56 |