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The incidence of insulin-treated T1D in the first 35 years of life. Cases with multiple autoantibodies have different features (as illustrated) than those with single autoantibodies, even before diagnosis. Redondo et al. (2) now find that the TCF7L2 locus, previously associated with type 2 diabetes, protects single-autoantibody children from progressing to multiple autoantibodies, which are associated with a greater risk and earlier onset of T1D.
