Table 3.

Multivariable association of FG CV during young adulthood with cognitive function at examination year 30 (2015–2016)

	Difference in year 30 cognitive test score per 1 SD CV-FG (95% CI)
	Model 1*	Model 2†	Model 3‡	Model 3A§	Model 3B‖	Model 3C¶
DSST, n = 2,996	−1.00 (−1.55, −0.45)	−0.43 (−0.95, 0.10)	−0.38 (−0.91, 0.15)	−0.39 (−0.92, 0.14)	−0.77 (−1.43, −0.10)	−0.32 (−0.86, 0.22)
RAVLT, n = 3,011	−0.16 (−0.27, −0.04)	−0.07 (−0.18, 0.04)	−0.07 (−0.19, 0.04)	−0.07 (−0.19, 0.04)	−0.10 (−0.24, 0.04)	−0.06 (−0.18, 0.05)
Stroop Test, n = 2,939	0.26 (−0.15, 0.67)	−0.02 (−0.43, 0.38)	−0.03 (−0.43, 0.38)	−0.02 (−0.42, 0.39)	0.07 (−0.44, 0.58)	−0.03 (−0.45, 0.38)
MoCA, n = 2,994	−0.23 (−0.36, −0.10)	−0.11 (−0.23, 0.01)	−0.10 (−0.22, 0.02)	−0.11 (−0.23, 0.01)	−0.21 (−0.36, −0.06)	−0.11 (−0.23, 0.01)
Category fluency, n = 2,986	−0.17 (−0.36, 0.02)	−0.06 (−0.25, 0.13)	−0.07 (−0.26, 0.12)	−0.09 (−0.28, 0.10)	−0.21 (−0.44, 0.03)	−0.09 (−0.28, 0.10)
Letter fluency, n = 2,938	−0.40 (−0.86, 0.06)	−0.06 (−0.51, 0.39)	−0.04 (−0.49, 0.41)	−0.10 (−0.55, 0.35)	−0.22 (−0.78, 0.35)	−0.04 (−0.50, 0.42)
Global z score, n = 2,852	−0.06 (−0.09, −0.02)	−0.02 (−0.05, 0.01)	−0.02 (−0.05, 0.01)	−0.02 (−0.05, 0.01)	−0.03 (−0.07, 0.004)	−0.02 (−0.05, 0.01)

A 1-SD unit increment in CV-FG at year 30 is 3.3%.

*Model 1 adjustments: age, sex, race, field center.

†Model 2 adjustments: model 1 adjustments plus highest level of educational attainment and cumulative values for number of years as a current smoker, grams of alcohol consumed weekly, BMI, physical activity, systolic BP, use of BP-lowering medications, LDL-C, and use of cholesterol-lowering medications.

‡Model 3 adjustments: model 2 adjustments plus weighted average of FG.

§Model 3A adjustments: model 3 adjustments plus the incidence of diabetes, diabetes medication use, and diabetes duration.

‖Model 3B adjustments: model 3 adjustments plus change in FG level during variability measurement.

¶Model 3C adjustments: model 3 adjustments plus year 30 FG level.