Figure 5.

CETP inhibition increased liver lipid content, which was associated with increased inflammation in HFD-fed mice. A–E: Liver content for TG, NEFA, DGs, cholesterol, and phospholipids. F: VLDL production rates were determined with CETP male mice that were fed an HFD for 1 month and treated with anacetrapib or vehicle. G–I: mRNA levels for SAA1, IL-6, and TNFα were determined by real-time PCR. mRNA levels in vehicle-treated chow-fed mice were set as 1. Data are mean ± SD (n ≥ 6). Significant differences were determined using two-way ANOVA with Bonferroni multiple comparison test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Ana, anacetrapib; Veh, vehicle.