Table 1.
The demographic characteristics and results of laboratory tests in examined patients
| Parameter | PBC patients (n = 40) | Controls (n = 20) | p value |
|---|---|---|---|
| Stage of disease | I, 7 pts; II, 16 pts; III, 11 pts; IV, 6 pts | ||
| Presence of pruritus | n = 18 | ||
| AMA positivity (≥ 1:40) | n = 40 | ||
| Age (years) | 52.4 ± 12.5 | 49.8 ± 6.7 | NS |
| Gender F/M | 34/0 | 20/0 | NS |
| ALP activity [U/l] | 254.2 ± 98.2 | 98.1 ± 27.2 | 0.0015* |
| GGT activity [U/l] | 245.2 ± 125.8 | 39.67 ± 16.5 | 0.0001* |
| ALT [U/l] | 67.3 ± 28.5 | 24.0 ± 11.7 | 0.0325* |
| AST [U/l] | 43.1 ± 17.4 | 21.8 ± 8.2 | NS |
| Prothrombin time [s] | 12.8 ± 1.3 | 12.1 ± 2.3 | NS |
| Bilirubin [mg/dl] | 3.4 ± 1.8 | 0.8 ± 0.4 | 0.0032* |
| IgM [IU/ml] | 317.9 ± 115.2 | 327.3 ± 127.5 | NS |
| IgG [IU/ml] | 1345.3 ± 234.7 | 1543 ± 247.9 | NS |
| Albumin [g/dl] | 3.6 ± 1.3 | 3.9 ± 1.0 | NS |
| PTC [109/l] | 197.4 ± 67.3 | 234.8 ± 98.4 | NS |
Age and results of laboratory tests are presented as mean ± SD (standard deviation)
NS not significant, n number of patients, pts patients, AMA antimitochondrial antibodies, F females, M males, ALS alcoholic liver steatosis, ALT alanine aminotransferase, ASH alcoholic steatohepatitis, AST aspartate transaminase, ALP alkaline phosphatase, GGT gamma-glutamyl transferase, IgM immunoglobulin M, IgG immunoglobulin G, PTC platelet count
*Statistically significant differences vs. controls, p < 0.05