Table 1.
Effects of compounds 1 and 2 on the platelet aggregation induced by Thr, AA, collagen, and PAF in washed rabbit platelets.
| Compound | Aggregation (%) | |||
|---|---|---|---|---|
| Thr (0.1 U/mL) | AA (100 μM) | Col. (10 μg/mL) | PAF (1 ng/mL) | |
| 1 (100 μg/mL) | 85.0±1.2* | 0.0±0.0*** | 0±0*** | 24.7±3.8*** |
| (50 μg/mL) | 73.7±3.3 | 27.0±11.5*** | 60.7±1.5*** | |
| (20 μg/mL) | 70.0±1.9** | |||
| 2 (100 μg/mL) | 74.3±0.5** | 53.0±2.2*** | 0±0*** | 70.0±1.2*** |
| (50 μg/mL) | 70.3±4.0** | 0±0*** | ||
| (20 μg/mL) | 63.7±5.5* | |||
| Control | 80.0±1.6 | 83.3±0.5 | 81.3±3.8 | 84.0±1.7 |
Platelets were preincubated with DMSO (0.5%, control), or tested compounds at 37 °C for 3 min, then Thr (0.1 U/mL), AA (100 μM), collagen (10 μg/mL) or PAF (1 ng/mL) was added. Percentages of aggregation are presented as means ± S. E. (n = 3~4).
* p<0.05, ** p<0.01, *** p<0.001 as compared with the respective control.