Table 1.
Incidence and median survival of patients diagnosed with CRC and identified brain metastases at diagnosis
| Subtype | Patients (no.)
|
Incidence proportion of brain metastases, %
|
Survival among patients with brain metastases, median (IQR), months | |||
|---|---|---|---|---|---|---|
| With CRC | With metastatic disease | With brain metastases | Among the entire cohort | Among the subset with metastatic disease | ||
|
| ||||||
| Whole cohort | 170,793 | 31,544 | 401 | 0.2% | 1.3% | 21.95 (21.87-22.03) |
| RCC | 69,147 (40.5%) | 12,451 (18.0) | 167 (0.2%) | 0.2% | 1.3% | 9.01 (7.0-11.15) |
| LCC | 44,642 (26.1%) | 8,797 (19.7%) | 92 (0.2%) | 0.2% | 1.0% | 10.26 (7.68-12.85) |
| Rectosigmoid cancer | 52,784 (30.9%) | 9,084 (17.2%) | 139 (0.3%) | 0.3% | 1.5% | 14.57 (11.89-17.26) |
| Appendix cancer | 4,220 (2.5%) | 1,212 (28.7%) | 3 (0.1%) | 0.1% | 0.3% | 5 (0.84-9.16) |
| Extracranial metastasis to | ||||||
| bone, lung, and liver (no.) | ||||||
| 0 sites | 145,175 | 110 | 0.1% | 15.59 (11.60-19.59) | ||
| Bone | 357 | 12 | 3.4% | 10.53 (3.96-17.11) | ||
| Lung | 1,999 | 55 | 2.8% | 11.66 (8.35-14.97) | ||
| Liver | 168,22 | 64 | 0.4% | 10.52 (7.02-14.02) | ||
| Two sites | 5,400 | 121 | 2.2% | 8.85 (7.12-10.57) | ||
| All three sites | 540 | 39 | 6.6% | 7.34 (4.82-9.86) | ||
Abbreviations: CRC, colorectal cancer; LCC, left-sided colon cancer; RCC, right-sided colon cancer; IQR, interquartile range.