. 2018 Nov 15;10:5639–5647. doi: 10.2147/CMAR.S175489

Table 1.

Associations between CTCs and clinical data and immunohistochemical markers

Type	Pre-CTCs		P-value	Pre-CTCs		P-value	Post-CTCs		P-value	Post-CTCs		P-value	Change-CTCs		P-value
Type	≤2	>2	P-value	≤5	>5	P-value	≤2	>2	P-value	≤5	>5	P-value	Reduce	Rise	P-value

Gender			0.611			0.088			0.731			>0.999			0.139
Male	16	21		26	11		15	22		27	10		20	17
Female	1	4		1	4		3	2		4	1		5	0
AFP (ng/mL)			0.804			0.879			0.554			>0.999			0.804
<400	13	17		20	10		12	18		22	8		17	13
≥400	4	8		7	5		6	6		9	3		8	4
Age (years)			0.324			0.85			0.463			0.222			0.024
≥47	8	8		10	6		8	8		14	2		13	3
<47	9	17		17	9		10	16		17	9		12	14
HBV-DNA			0.276			0.353			0.15			0.389			0.037
<5.0×10²	9	9		13	5		10	8		15	3		14	4
≥5.0×10²	8	16		14	10		8	16		16	8		11	13
Edmondson stage			0.044			0.014			0.353			0.060			0.542
I, II	14	13		21	6		13	14		23	4		17	10
III, IV	3	12		6	9		5	10		8	7		8	7
TNM stage			0.511			0.478			>0.999			0.836			0.152
I, II	15	22		25	12		16	21		28	9		24	13
III, IV	2	3		2	3		2	3		3	2		1	4
BCLC stage			0.312			0.666			0.100			>0.999			0.834
A, B	12	22		20	14		12	22		25	9		21	13
C, D	5	3		7	1		6	2		6	2		4	4
PVTT			0.158			0.53			0.178			1.00			>0.999
Yes	2	0		2	0		2	0		2	0		1	1
No	15	25		25	15		16	24		29	11		24	16
Tumor size (cm)			>0.999			>0.999			0.554			0.781			0.655
>5	5	7		8	4		6	6		8	4		6	6
≤5	12	18		19	11		12	18		23	7		19	11
Number of tumors			0.160			>0.999			0.676			0.754			0.160
Singleton	12	23		22	13		16	19		25	10		23	12
Multiple	5	2		5	2		2	5		6	1		2	5
P21			0.861			>0.999			0.951			>0.999			0.861
Positive (+)	3	3		4	2		3	3		4	2		3	3
Negative (−)	12	21		19	12		12	19		25	8		21	12
NM23			>0.999			0.375			>0.999			0.275			0.400
Positive (+)	15	24		25	14		16	23		29	10		24	15
Negative (−)	0	1		0	1		0	1		0	1		0	1
VEGF+			0.332			0.945			0.501			0.525			0.987
Positive (+)	7	15		14	8		8	14		15	7		13	9
Negative (−)	8	9		11	6		8	9		14	3		10	7
CD34			>0.999			0.385			>0.999			>0.999			>0.999
Positive (+)	15	23		24	14		15	23		27	11		21	17
Negative (−)	0	1		0	1		0	1		1	0		1	0

Note: Bold values indicate statistically significant values.

Abbreviations: CTC, circulating tumor cell; BCLC, Barcelona Clinic Liver Cancer; HBV-DNA, hepatitis B virus DNA; AFP, alpha-fetoprotein; VEGF, vascular endothelial growth factor; PVTT, portal vein tumor thrombosis.