Table 3.
Cox regression analysis of associations between CTC counts and survival in patients with HBV-related HCC
| Variables | Patients (n=42) | Overall survival
|
Progression-free survival
|
||
|---|---|---|---|---|---|
| HRa (95% CI) | P-valuea | HRa (95% CI) | P-valuea | ||
|
| |||||
| Postoperative CTC counts | |||||
| ≤2 | 18 | 1 | 1 | ||
| >2 | 24 | 1.16 (0.047–28.25) | 0.379 | 8.72 (1.40–54.17) | 0.020 |
| Postoperative CTC counts | |||||
| ≤5 | 31 | 1 | 1 | ||
| >5 | 11 | 15.65 (0.80–304.64) | 0.069 | 6.89 (1.64–29.00) | 0.009 |
| CTC change | |||||
| Reduce | 25 | 1 | 1 | ||
| Rise | 17 | NA | 0.964 | 39.58 (4.22–371.64) | 0.001 |
Notes:
a
HR and P-value for Cox proportional hazard regression model. Adjustment by Tumor, Node, Metastases or Barcelona Clinic Liver Cancer stage, number of tumors, diameter of tumors, age, and gender.
Abbreviations: CTC, circulating tumor cell; AFP, alpha-fetoprotein; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HR, hazard ratio; Ref., reference; NA, not available.