Figure 2.

(A) Survival of BALB/c mice with XDRAB infection after treatment with different MOIs (10, 1, and 0.1) of phage φkm18p. Kaplan–Meier survival curves were obtained from mice infected with a lethal dose of ip KM18 (3×10⁸ CFU) in BALB/c mice. ^***P-value <0.001 compared to the no phage control. Mice that received φkm18p therapy at a 1-hour delay after KM18 injection (MOI=1) showed a significantly different Kaplan–Meier survival curve compared to mice that received immediate phage therapy; ^*P=0.014. (B) Survival of C57BL/6 mice with ip KM18 (6×10⁸ CFU) (MOI =1); ^**P=0.0106. The survival rate of mice was observed after 10 days. The control group was injected with PBS (no phage control). Kaplan–Meier survival rate analysis shows that the immediate injection of bacteriophages has a significantly different survival than the 1-hour delayed group and the no phage control.

Abbreviations: CFU, colony-forming units; ip, intraperitoneal; MOIs, multiplicities of infection; XDRAB, extensively drug-resistant Acinetobacter baumannii.