Table 2.
Univariate and multivariate analyses of prognostic variables for overall survival in HCC patients
| Clinicopathological features | Univariate analysis
|
Multivariate analysis
|
||||
|---|---|---|---|---|---|---|
| HR | 95% (CI) | P-value | HR | 95% (CI) | P-value | |
|
| ||||||
| Age (years) | ||||||
| < Median | 1.000 | 0.389 | ||||
| > Median | 1.189 | 0.802–1.765 | ||||
| Race | ||||||
| Yellow | 1.000 | 0.695 | ||||
| White | 1.082 | 0.730–1.603 | ||||
| Gender | ||||||
| Female | 1.000 | 0.295 | ||||
| Male | 1.243 | 0.828–1.866 | ||||
| AFP (ng/mL) | ||||||
| <20 | 1.000 | 0.046* | 1.000 | 0.074 | ||
| >20 | 1.519 | 0.436–0.993 | 1.458 | 0.964–2.204 | ||
| TNM stage | ||||||
| Stage I–II | 1.000 | <0.001** | 1.000 | 0.001** | ||
| Stage III–IV | 2.631 | 1.765–3.920 | 2.466 | 1.649–3.687 | ||
| Histological type | ||||||
| Non-HCC | 1.000 | 0.454 | ||||
| HCC | 2.126 | 0.296–15.270 | ||||
| Differentiation grade | ||||||
| Grade 1–2 | 1.000 | 0.251 | ||||
| Grade 3–4 | 1.261 | 0.849–1.872 | ||||
| ENO1 expression | ||||||
| Low | 1.000 | <0.001** | 1.000 | 0.003** | ||
| High | 2.073 | 1.383–3.107 | 1.861 | 1.236–2.802 | ||
Notes:
*
P<0.05.
**
P<0.01.
Abbreviations: AFP, α-fetoprotein; ENO1, enolase-1; HCC, hepatocellular carcinoma.