Figure 3.

Number of L929 cells incubated for 48h with either unloaded granules (UG), granules containing 5-FU produced at 80°C (LG80) and 120°C (LG120) or free 5-FU of corresponding concentrations. The cell count is expressed as percentage of the control (n=12).

***: UG 100 µg/mL vs. LG80 100 µg/mL, LG120 100 µg/mL p<0.001

o: UG 10 µg/mL vs. LG80 10 µg/mL, LG120 10 µg/mL p<0.001

#: LG80 10 µg/mL vs. 250 ng/mL 5-FU p<0.01; +: LG120 10 µg/mL vs. 250 ng/mL 5-FU p<0.05