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Number of ROS 17/2.8 cells incubated for 72h with either unloaded granules (UG), granules containing 5-FU produced at 80°C (LG80) and 120°C (LG120) or free 5-FU of corresponding concentrations. The cell count is expressed as percentage of the control (n=12).
***: UG 100 µg/mL vs. LG80 100 µg/mL, LG120 100 µg/mL p<0.001
o: UG 10 µg/mL vs. LG80 10 µg/mL, LG120 10 µg/mL p<0.001
∆: UG 1 µg/mL vs. LG80 1 µg/mL p<0.01
