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. 2008 Mar 18;13(3):603–615. doi: 10.3390/molecules13030603

Table 3.

Index variable for the substitution burden for compounds 1 to 6.

Compound log ED50 Relative
extent of
substitution
Ibuprofen 1.412 2
1 2.142 0
2 1.910 2
3 1.699 1
4 2.337 1
5 1.152 3
6 1.846 1